The production and up-regulation of inflammatory mediators are contributing factors for the development and maintenance of neuropathic pain.In the present study, the post-treatment of synthetic 1,3,4 oxadiazole derivative (B3) for its neuroprotective potential in chronic constriction injury-induced neuropathic pain was applied.In-silico studies wer
An investigation of the effects of osteoporosis, impact intensity and orientation on human femur injuries: a parametric finite element study
Objective: Femur is the strongest, longest and heaviest bone in the human body.Due Spur Pads to the great importance of femur in human body, its injury may cause large numbers of disabilities and mortality.Considering various effective parameters such as mechanical properties, geometry, loading configuration, etc.can propel the study to the trustab
Foliar plasticity of Erythroxylum tortuosum (Erythroxylaceae) in the Cerrado: a representative neotropical genus with medicinal importance
Abstract Erythroxylum is common in the Brazilian Cerrado.Species from this genus have ecological, pharmacological and popular medical importance.Based on this information, the aims of this study was to perform a descriptive and quantitative morphoanatomical study of Erythroxylum tortuosum leaves present in two environments: cerrado sensu stricto an
Oxidative and Endoplasmic Reticulum Stress Represent Novel Therapeutic Targets for Choroideremia
Choroideremia (CHM) is a rare X-linked chorioretinal dystrophy, affecting the photoreceptors, retinal pigment epithelium (RPE) and choroid, with no approved therapy.CHM is caused by mutations in the CHM gene, which encodes the ubiquitously expressed Rab escort protein 1 (REP1).REP1 is involved in prenylation, a post-translational modification of Ha